코로나바이러스감염증-19

From Biopedia.kr

코로나바이러스감염증-19

(Coronavirus disease-19, COVID-19)는 2019년 중국에서 확인된 2019년 신종 코로나바이러스 (SARS-CoV-2)에 의해 발병하는 폐렴이다.

 

이전의 바이러스들과는 다른 강력한 전염성과, 빠른 증상 악화등 기존의 코로나바이러스 유행에 비해 심각하다. 그럼에도 불구하고 일단 코로나 바이러스라고 아무 증상 없이 그냥 지나가거나, 평범한 감기 수준으로 끝나는 경우가 있어 환자 격리 등의 대응이 매우 어려운 상태. 
 

https://wuhanvirus.kr 코로나 실시간 상황판

Corona_Virus_case_1_travel_paths_in_English

 

<2020년 2월 현재 개발된 진단키트 종류>

TABLE 1 | SELECTED DIAGNOSTIC TESTS FOR SARS-COV-2

https://www.nature.com/articles/d41587-020-00002-2 에서 가져옴.

네이쳐 2월 19일 코로나바이러스 관련 특렬 기사

Developer

Test

Description

Current status

Chinese National Institute for Viral Disease Control and Prevention

New coronavirus nucleic acid assay

Primers and probes for detecting the novel coronavirus with RT-PCR

In widespread distribution in China

US Centers for Disease Control and Prevention (CDC)

CDC 2019-nCoV real-time reverse transcriptase PCR diagnostic panel

PCR test that runs on Applied Biosystems 7500 Fast Dx RT-PCR instrument with SDS 1.4 software

Emergency Use Authorization (EUA) granted by the FDA on 4 February

University of Hong Kong

Real-time reverse transcriptase PCR assays

Two single-step quantitative RT reverse transcription PCR assays for N gene and ORF1b of sarbecovirus subgenus

Reference test shipped to WHO and to over 30 labs globally

Amoy Diagnostics (Xiamen, China)

Coronavirus gene detection kit

PCR-based rapid detection kit

Seeking emergency approval from China’s National Medical Products Administration

Altona Diagnostics (Hamburg, Germany)

Real-time PCR assay

Rapid detection of coronavirus RNA from respiratory samples

In development; shipping expected end of February

BGI Group (Beijing)

Real-time fluorescent RT-PCR kit for detecting 2019-nCoV

Test results delivered in several hours

Emergency approval granted by China’s National Medical Products Administration

BGI Group

2019-nCoV nucleic acid detection kit using combinatorial probe-anchor synthesis method

Metagenomic sequencing kit for monitoring novel coronavirus mutations

Emergency approval granted by China’s National Medical Products Administration

Hong Kong University of Science and Technology

On-site rapid molecular diagnostic system based on Shenzhen Shineway Technology

Integrated microfluidic PCR test employing silicon-based micro-heater module for rapid heating and processing of test samples; delivers test results in 40 minutes

Platform has European Union CE approval

Novacyt, Primerdesign

Novel Coronavirus Strain 2019-nCoV

Runs on portable genesig16 RT-PCR instrument; delivers test results in less than two hours

CE-marked research-use-only test launched 17 February; seeking FDA EUA

Thermo Fisher Scientific

TaqMan 2019-nCoV Assay Kit

Lab PCR test that runs on Applied Biosystems 7500 RT-PCR system; identifies sequences found in initial 44 SARS-CoV-2 genomes

Research use only

Qiagen (Hilden, Germany)

QIAstat-Dx Respiratory 2019-nCoV Panel

Integrated sample prep and RT-PCR detection of 21 respiratory pathogens; samples and reagents delivered in assay cartridges and analyzed in desktop QIAstat-Dx Analyzer; results delivered in one hour

Prototype panel including COVID-19 test shipped on 11 February for clinical performance assessment in China and Europe

Biomeme

Biomeme COVID-19 Go-Strips

Integrated sample prep and RNA detection test that runs on Biomeme’s mobile handheld quantitative PCR device