NCBI Pubmed search with Fenbendazole cancer

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Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells.

Mrkvová Z, Uldrijan S, Pombinho A, Bartůněk P, Slaninová I.

Molecules. 2019 Jun 7;24(11). pii: E2152. doi: 10.3390/molecules24112152.

 

Drug library screen reveals benzimidazole derivatives as selective cytotoxic agents for KRAS-mutant lung cancer.

Shimomura I, Yokoi A, Kohama I, Kumazaki M, Tada Y, Tatsumi K, Ochiya T, Yamamoto Y.

Cancer Lett. 2019 Jun 1;451:11-22. doi: 10.1016/j.canlet.2019.03.002. Epub 2019 Mar 9.

 

Cellular immune responses in peripheral blood lymphocytes of Giardia infected squirrel monkey (Saimiri boliviensis boliviensis) treated with Fenbendazole.

Nehete PN, Wilkerson G, Nehete BP, Chitta S, Ruiz JC, Scholtzova H, Williams LE, Abee CR, Vanchiere JA.

PLoS One. 2018 Nov 9;13(11):e0198497. doi: 10.1371/journal.pone.0198497. eCollection 2018.

 
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Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways.

Dogra N, Kumar A, Mukhopadhyay T.

Sci Rep. 2018 Aug 9;8(1):11926. doi: 10.1038/s41598-018-30158-6.

 
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Discovery of genomic intervals that underlie nematode responses to benzimidazoles.

Zamanian M, Cook DE, Zdraljevic S, Brady SC, Lee D, Lee J, Andersen EC.

PLoS Negl Trop Dis. 2018 Mar 30;12(3):e0006368. doi: 10.1371/journal.pntd.0006368. eCollection 2018 Mar.

 
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In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells.

Lai SR, Castello SA, Robinson AC, Koehler JW.

Vet Comp Oncol. 2017 Dec;15(4):1445-1454. doi: 10.1111/vco.12288. Epub 2017 Jan 12.

 
 

Identification of epigenetically downregulated Tmem70 and Ube2e2 in rat liver after 28-day treatment with hepatocarcinogenic thioacetamide showing gene product downregulation in hepatocellular preneoplastic and neoplastic lesions produced by tumor promotion.

Mizukami S, Yafune A, Watanabe Y, Nakajima K, Jin M, Yoshida T, Shibutani M.

Toxicol Lett. 2017 Jan 15;266:13-22. doi: 10.1016/j.toxlet.2016.11.022. Epub 2016 Nov 30.

 

What Is Your Diagnosis? Inflammatory granuloma.

Ruiz GC, Benchekroun G.

J Am Vet Med Assoc. 2016 May 1;248(9):995-7. doi: 10.2460/javma.248.9.995. No abstract available.

 

Expression patterns of cell cycle proteins in the livers of rats treated with hepatocarcinogens for 28 days.

Yafune A, Taniai E, Morita R, Nakane F, Suzuki K, Mitsumori K, Shibutani M.

Arch Toxicol. 2013 Jun;87(6):1141-53. doi: 10.1007/s00204-013-1011-y. Epub 2013 Feb 15.

 

Fenbendazole as a potential anticancer drug.

Duan Q, Liu Y, Rockwell S.

Anticancer Res. 2013 Feb;33(2):355-62.

 

Intracranial migration of Eucoleus (Capillaria) boehmi in a dog.

Clark AC, López FR, Levine JM, Cooper JJ, Craig TM, Voges AK, Johnson MC, Porter BF.

J Small Anim Pract. 2013 Feb;54(2):99-103. doi: 10.1111/j.1748-5827.2012.01303.x. Epub 2012 Nov 12.

 

Use of fenbendazole-containing therapeutic diets for mice in experimental cancer therapy studies.

Duan Q, Liu Y, Booth CJ, Rockwell S.

J Am Assoc Lab Anim Sci. 2012 Mar;51(2):224-30.

 

Impairment of the ubiquitin-proteasome pathway by methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate leads to a potent cytotoxic effect in tumor cells: a novel antiproliferative agent with a potential therapeutic implication.

Dogra N, Mukhopadhyay T.

J Biol Chem. 2012 Aug 31;287(36):30625-40. doi: 10.1074/jbc.M111.324228. Epub 2012 Jun 28.

 

Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme.

Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ.

Neuro Oncol. 2011 Sep;13(9):974-82. doi: 10.1093/neuonc/nor077. Epub 2011 Jul 15.

 

Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model.

Ichimura R, Mizukami S, Takahashi M, Taniai E, Kemmochi S, Mitsumori K, Shibutani M.

Toxicol Appl Pharmacol. 2010 Aug 1;246(3):128-40. doi: 10.1016/j.taap.2010.04.016. Epub 2010 Apr 25.

 

Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.

Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M.

Arch Toxicol. 2010 Apr;84(4):319-31. doi: 10.1007/s00204-009-0496-x. Epub 2009 Dec 20.

 

Chronic myelogenous leukemia in a great horned owl (Bubo virginianus).

Wiley JL, Whittington JK, Wilmes CM, Messick JB.

J Avian Med Surg. 2009 Mar;23(1):36-43.

Crosstalk between PTEN/Akt2 and TGFbeta signaling involving EGF receptor down-regulation during the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.

Taniai E, Kawai M, Dewa Y, Nishimura J, Harada T, Saegusa Y, Matsumoto S, Takahashi M, Mitsumori K, Shibutani M.

Cancer Sci. 2009 May;100(5):813-20. doi: 10.1111/j.1349-7006.2009.01120.x. Epub 2009 Mar 20.

 

Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins.

Gao P, Dang CV, Watson J.

J Am Assoc Lab Anim Sci. 2008 Nov;47(6):37-40.

 

Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells.

Doudican N, Rodriguez A, Osman I, Orlow SJ.

Mol Cancer Res. 2008 Aug;6(8):1308-15. doi: 10.1158/1541-7786.MCR-07-2159. Epub 2008 Jul 30.

 

Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.

Takahashi M, Shibutani M, Woo GH, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A.

Carcinogenesis. 2008 Nov;29(11):2218-26. doi: 10.1093/carcin/bgn135. Epub 2008 Jun 26.

 

Nonsurgical resolution of gallbladder mucocele in two dogs.

Walter R, Dunn ME, d'Anjou MA, Lécuyer M.

J Am Vet Med Assoc. 2008 Jun 1;232(11):1688-93. doi: 10.2460/javma.232.11.1688.

 

Immunomodulatory effect of various anti-parasitics: a review.

Sajid MS, Iqbal Z, Muhammad G, Iqbal MU.

Parasitology. 2006 Mar;132(Pt 3):301-13. Epub 2005 Dec 7. Review.

 

Transport of anthelmintic benzimidazole drugs by breast cancer resistance protein (BCRP/ABCG2).

Merino G, Jonker JW, Wagenaar E, Pulido MM, Molina AJ, Alvarez AI, Schinkel AH.

Drug Metab Dispos. 2005 May;33(5):614-8. Epub 2005 Feb 9.

 

Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer.

Suzuki S, Takahashi S, Asamoto M, Inaguma S, Ogiso T, Hirose M, Shirai T.

Cancer Lett. 2002 Nov 8;185(1):39-45.

 

Liver tumor promoting effects of fenbendazole in rats.

Shoda T, Onodera H, Takeda M, Uneyama C, Imazawa T, Takegawa K, Yasuhara K, Watanabe T, Hirose M, Mitsumori K.

Toxicol Pathol. 1999 Sep-Oct;27(5):553-62.

 

Multisystemic, eosinophilic, epitheliotropic disease with intestinal lymphosarcoma in a horse.

La Perle KM, Piercy RJ, Long JF, Blomme EA.

Vet Pathol. 1998 Mar;35(2):144-6.

 

[Intensity of liver tumor promotion effects in rats given repeated oral administrations of benzimidazole compounds].

Onodera H, Mitsumori K, Uneyama C, Yasuhara K, Takegawa K, Takahashi M.

Eisei Shikenjo Hokoku. 1996;(114):21-6. Japanese.

 

Practical and effective eradication of pinworms (Syphacia muris) in rats by use of fenbendazole.

Coghlan LG, Lee DR, Psencik B, Weiss D.

Lab Anim Sci. 1993 Oct;43(5):481-7.

 

Effect of anthelminthic treatment on the immune response of mice.

Reiss CS, Herrman JM, Hopkins RE 2nd.

Lab Anim Sci. 1987 Dec;37(6):773-5.