Epigenome

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An epigenome consists of a record of the chemical changes to the DNA and histone proteins of an organism; these changes can be passed down to an organism's offspring via transgenerational epigenetic inheritance. Changes to the epigenome can result in changes to the structure of chromatin and changes to the function of the genome.1

The epigenome is involved in regulating gene expression, development, tissue differentiation, and suppression of transposable elements. Unlike the underlying genome, which remains largely static within an individual, the epigenome can be dynamically altered by environmental conditions.

 

Epigenome and Cancer

 

Epigenome research projects

 

Roadmap epigenomics project

 

See also

References

  1. ^ Bernstein, Bradley E.; Meissner, Alexander; Lander,Eric S. (February 2007). "The Mammalian Epigenome". Cell. 128 (4): 669–681. doi:10.1016/j.cell.2007.01.033. PMID 17320505.
  2. ^ "Human Epigenome Project". Archived from the original on 2011-07-16. Retrieved 2011-06-29.
  3. ^ Milosavljevic, Aleksandar (June 2011). "Emerging patterns of epigenomic variation". Trends in Genetics. 27 (6): 242–250. doi:10.1016/j.tig.2011.03.001. PMC 3104125. PMID 21507501.
  4. ^ Aguilar, Carlos; Craighead, Harold (October 4, 2013). "Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics". Nature Nanotechnology. 8 (10): 709–718. Bibcode:2013NatNa...8..709A. doi:10.1038/nnano.2013.195. PMC 4072028. PMID 24091454.
  5. ^ "Time for the epigenome". Nature. 463 (7281): 587. Feb 2010. Bibcode:2010Natur.463Q.587.. doi:10.1038/463587a. PMID 20130607.
  6. ^ Abbott, A (2010). "Project set to map marks on genome". Nature. 463 (7281): 596–597. doi:10.1038/463596b. PMID 20162836.
  7. ^ Bae, JB (2013). "Perspectives of international human epigenome consortium". Genomics Inform. 11 (1): 7–14. doi:10.5808/GI.2013.11.1.7. PMC 3630389. PMID 23613677.
  8. ^ "BioNews - Human Epigenome project launched".
  9. ^ "France: Human epigenome consortium takes first steps" Archived 2015-07-08 at the Wayback Machine. 5 March 2010.
  10. ^ Eurice GmbH. "About IHEC".
  11. ^ Kanai, Yae; Arai, Eri (2014). "Multilayer-omics analyses of human cancers: Exploration of biomarkers and drug targets based on the activities of the International Human Epigenome Consortium". Frontiers in Genetics. 5: 24. doi:10.3389/fgene.2014.00024. PMC 3924033. PMID 24592273.
  12. ^ Zhu, J.; et al. (2013). "Genome-wide chromatin state transitions associated with developmental and environmental cues". Cell. 152 (3): 642–654. doi:10.1016/j.cell.2012.12.033. PMC 3563935. PMID 23333102.
  13. ^ Harris, R Alan; Wang, Ting; Coarfa, Cristian; Nagarajan, Raman P; Hong, Chibo; Downey, Sara L; et al. (September 19, 2010). "Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications". Nature Biotechnology. 28 (10): 1097–1105. doi:10.1038/nbt.1682. PMC 2955169. PMID 20852635.

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