지속태아혈색소증 혹은 태아혈액지속증은 상당한 양의 태아 헤모글로빈이 성인이 된후에도 계속 생산되는 것을 말합니다. 아기 몸속에서 산소를 나르는 헤모글로빈을 헤모글로빈F라고 하는데 이것이 계속 생산되는 것입니다. 이것의 원인은 유전적으로 베타-글로빈 유전자에 돌연변이가 생겨서 그런 것입니다. 흑인과 그리스사람들에게 많이 나타나는 일종의 유전성 질환입니다.
Hereditary persistence of fetal hemoglobin (HPFH, BrE: Hereditary persistence of foetal haemoglobin) is a benign condition in which significant fetal hemoglobin (hemoglobin F) production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.1
Causes
This is usually caused by mutations in the β-globin gene cluster.title="Wikipedia:Citation needed" href="/wiki/Wikipedia:Citation_needed">citation needed The percentage of incorrect expression might be as low as 10-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes.2
Epidemiology
HPFH may alleviate the severity of certain hemaglobinopathies and thalassemias, and is selected for in populations with a high prevalence of these conditions (which in turn are often selected for in areas where malaria is endemic). Thus, it has been found to affect black people, as well as Greeks.3
Presentation
The condition is usually asymptomatic, and is only noticed when screening for other hemoglobin disorders.
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