Glabridin

Glabridin is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra).^{is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols. Glabridin effectively inhibits platelet activation, so it might become therapeutic agent for thromboembolic disorders.^[3}

It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI).

Glabridin is yellowish-brown powder. It is insoluble in water, but soluble in organic solvents such as propylene glycol.

References

^ SciFinder Record for CAS#59870-68-7
^ Kinoshita, Takeshi; Kajiyama, Kiichiro; Hiraga, Yukio; Takahashi, Kunio; Tamura, Yukiyoshi; Mizutani, Kenji (1996). "Isoflavan derivatives from Glycyrrhiza glabra (licorice)". Heterocycles. 43 (3): 581–588.
^ Chung, C. L., Chen, J. H., Huang, W. C., Sheu, J. R., Hsia, C. W., Jayakumar, T., ... & Hou, S. M. (2022). "Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice". International Journal of Molecular Sciences, 23(19), 11372. doi:10.3390/ijms231911372